mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
214 |
4. Check minimum number of eventsNone |
214 |
5. Include endpointsNone |
214 |
6. Filter based on genotype QC (FinnGen only) |
201 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Moderate mental retardation based on the number of shared cases.
Similar with more cases:
- Mental retardation
- Mental retardation
- Mental retardation
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 8871 | 3898 | 4958 |
Only index persons | 7776 | 3383 | 4393 |
Unadjusted period prevalence (%) | |||
Whole population | 0.13 | 0.11 | 0.14 |
Only index persons | 0.15 | 0.12 | 0.17 |
Median age at first event (years) | |||
Whole population | 20.27 | 22.12 | 18.75 |
Only index persons | 19.66 | 21.47 | 18.26 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 201 | 99 | 102 |
Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.05 |
Median age at first event (years) | 21.36 | 22.82 | 19.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_MODRET and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
F5_MODRET | 6.615 [5.16, 8.48] | < 0.001 |
Birth year | 0.993 [0.98, 1.0] | 0.1 |
During the follow-up period (1.1.1998 — 31.12.2019), 265 out of 1858 females with F5_MODRET died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
F5_MODRET | 3.444 [2.87, 4.13] | < 0.001 |
Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 284 out of 2621 males with F5_MODRET died.
Mortality risk
Mortality risk for people of age
years, who have F5_MODRET.N-year risk | Females | Males |
---|---|---|
1 | 0.543% | 0.549% |
5 | 3.359% | 3.302% |
10 | 8.41% | 8.733% |
15 | 16.665% | 16.144% |
20 | 26.975% | 26.716% |
Relationships between endpoints
↥Index endpoint: F5_MODRET – Moderate mental retardation
GWS hits: 1