obsolete_behavioural disease: ['A disease of or relating to the manner that an organism conducts itself involving action and response to stimulation or the response of an individual, group, or species to its environment.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3291 |
4. Check minimum number of eventsNone |
3291 |
5. Include endpointsNone |
3291 |
6. Filter based on genotype QC (FinnGen only) |
3129 |
Control definitions (FinnGen only)
Control exclude
F5_UNSMENDIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F99-F99
Name in latin
Perturbatio mentis non aliter specificata
Mental disorders, not otherwise specified
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 33576 | 19827 | 13587 |
| Only index persons | 32035 | 19194 | 12841 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.49 | 0.57 | 0.38 |
| Only index persons | 0.62 | 0.71 | 0.49 |
| Median age at first event (years) | |||
| Whole population | 34.54 | 35.07 | 33.75 |
| Only index persons | 34.02 | 34.58 | 33.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3129 | 2132 | 997 |
| Unadjusted period prevalence (%) | 0.73 | 0.84 | 0.50 |
| Median age at first event (years) | 37.73 | 36.24 | 40.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_MENTALUNSPE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MENTALUNSPE | 2.077 [1.86, 2.32] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.056 |
During the follow-up period (1.1.1998 — 31.12.2019), 1535 out of 18312 females with F5_MENTALUNSPE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MENTALUNSPE | 2.486 [2.21, 2.8] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.04 |
During the follow-up period (1.1.1998 — 31.12.2019), 1533 out of 12281 males with F5_MENTALUNSPE died.
Mortality risk
Mortality risk for people of age
years, who have F5_MENTALUNSPE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.161% | 0.439% |
| 5 | 1.018% | 3.168% |
| 10 | 2.601% | 7.074% |
| 15 | 4.98% | 13.534% |
| 20 | 8.856% | 23.4% |
Relationships between endpoints
↥Index endpoint: F5_MENTALUNSPE – Mental disorders, not otherwise specified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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