bipolar disorder: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1122 |
4. Check minimum number of eventsNone |
1122 |
5. Include endpointsNone |
1122 |
6. Filter based on genotype QC (FinnGen only) |
1061 |
Control definitions (FinnGen only)
Control exclude
F5_MOOD
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F30-F39
Name in latin
Mania
Similar endpoints
↥List of similar endpoints to
Manic episode
based on the number of shared cases.
Similar with more cases:
- Mood [affective] disorders
- Mood disorders
- Mood disorders
- Affective disorder, aux endpoint for F5_SAD
- Any mental disorder
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8563 | 4317 | 4191 |
| Only index persons | 7736 | 3974 | 3762 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.12 | 0.12 |
| Only index persons | 0.14 | 0.15 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 47.10 | 47.61 | 46.64 |
| Only index persons | 45.55 | 45.98 | 45.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1061 | 595 | 466 |
| Unadjusted period prevalence (%) | 0.23 | 0.23 | 0.23 |
| Median age at first event (years) | 44.33 | 42.25 | 46.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_MANIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MANIA | 2.482 [2.14, 2.88] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.039 |
During the follow-up period (1.1.1998 — 31.12.2019), 843 out of 3677 females with F5_MANIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MANIA | 3.049 [2.61, 3.56] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 945 out of 3517 males with F5_MANIA died.
Mortality risk
Mortality risk for people of age
years, who have F5_MANIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.167% | 0.515% |
| 5 | 1.046% | 3.524% |
| 10 | 2.924% | 8.751% |
| 15 | 5.769% | 16.259% |
| 20 | 10.569% | 25.66% |
Relationships between endpoints
↥Index endpoint: F5_MANIA – Manic episode
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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