Gender identity disorders

F5_GENDER

gender identity disorder: A disorder characterized by a strong and persistent cross-gender identification (such as stating a desire to be the other sex or frequently passing as the other sex) coupled with persistent discomfort with his or her sex (manifested in adults, for example, as a preoccupation with altering primary and secondary sex characteristics through hormonal manipulation or surgery).

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F64
  • Hospital discharge: ICD-9 3023|302[5-6]
  • Hospital discharge: ICD-8 3023
  • Cause of death: ICD-10 F64
  • Cause of death: ICD-9 3023|302[5-6]
  • Cause of death: ICD-8 3023

2 out of 7 registries used, show all original rules.

453

4. Check minimum number of events

None

453

5. Include endpoints

None

453

6. Filter based on genotype QC (FinnGen only)

433

Control definitions (FinnGen only)

Control exclude F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F63-F69
Name in latin Perturbationes identitatis generis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5826 3422 2338
Only index persons 5682 3391 2291
Unadjusted period prevalence (%)
Whole population 0.08 0.10 0.07
Only index persons 0.11 0.12 0.09
Median age at first event (years)
Whole population 22.20 20.84 23.99
Only index persons 22.03 20.81 23.84

-FinnGen-

Key figures

All Female Male
Number of individuals 433 295 138
Unadjusted period prevalence (%) 0.10 0.12 0.07
Median age at first event (years) 25.63 23.48 30.21

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint F5_GENDER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have F5_GENDER.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: F5_GENDER – Gender identity disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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