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Dissocial personality disorder

DOID EFO Endpoint Browser PheWeb

F5_DISPER

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F60.2
  • Hospital discharge: ICD-9 — 3017
  • Hospital discharge: ICD-8 — 3017
  • Cause of death: ICD-10 — F60.2
  • Cause of death: ICD-9 — 3017
  • Cause of death: ICD-8 — 3017

2 out of 7 registries used, show all original rules.

571

4. Check minimum number of events

None

571

5. Include endpoints

None

571

6. Filter based on genotype QC (FinnGen only)

535

Control definitions (FinnGen only)

Control exclude F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F60
Name in latin Personalitas dissocialis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7991 1125 6739
Only index persons 6256 973 5283
Unadjusted period prevalence (%)
Whole population 0.17 0.03 0.19
Only index persons 0.18 0.04 0.20
Median age at first event (years)
Whole population 28.39 29.74 28.02
Only index persons 28.01 29.18 27.79

-FinnGen-

Key figures

All Female Male
Number of individuals 535 111 424
Unadjusted period prevalence (%) 0.18 0.04 0.21
Median age at first event (years) 28.84 31.53 28.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_DISPER and mortality.

Females

Parameter HR [95% CI] p-value
F5_DISPER 6.697 [4.25, 10.56] < 0.001
Birth year 1.001 [0.99, 1.01] 0.793

During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 656 females with F5_DISPER died.

Males

Parameter HR [95% CI] p-value
F5_DISPER 7.174 [6.34, 8.11] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 600 out of 3076 males with F5_DISPER died.

Mortality risk

Mortality risk for people of age

years, who have F5_DISPER.

N-year risk Females Males
1 0.715% 1.379%
5 4.774% 7.726%
10 11.51% 18.512%
15 21.053% 32.315%
20 34.369% 49.806%

Relationships between endpoints

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Index endpoint: F5_DISPER – Dissocial personality disorder

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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