unipolar depression: A mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
55662 |
4. Check minimum number of eventsNone |
55662 |
5. Include endpoints |
55700 |
6. Filter based on genotype QC (FinnGen only) |
53313 |
Control definitions (FinnGen only)
Control exclude
F5_MOOD
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Depression
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 53313 | 36118 | 17195 |
| Unadjusted period prevalence (%) | 12.40 | 14.19 | 8.64 |
| Median age at first event (years) | 41.50 | 39.48 | 45.74 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: F5_DEPRESSIO – Depression
GWS hits: 23
This endpoint is excluded (different definition than used in FinnGen).