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Bipolar affective disorders

DOID EFO Endpoint Browser PheWeb

F5_BIPO

bipolar disorder: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F31
  • Hospital discharge: ICD-9 — 296[2-7]
  • Hospital discharge: ICD-8 — 296
  • Hospital discharge: excluded ICD-8 — 2960|29699
  • Cause of death: ICD-10 — F31
  • Cause of death: ICD-9 — 296[2-7]
  • Cause of death: ICD-8 — 296
  • Cause of death: excluded ICD-8 — 2960|29699

2 out of 7 registries used, show all original rules.

8544

4. Check minimum number of events

None

8544

5. Include endpoints

None

8544

6. Filter based on genotype QC (FinnGen only)

8209

Control definitions (FinnGen only)

Control exclude F5_MOOD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F30-F39
Name in latin Perturbatio affectiva bipolaris

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 65195 36677 28025
Only index persons 58650 33814 24836
Unadjusted period prevalence (%)
Whole population 0.93 1.05 0.78
Only index persons 1.12 1.24 0.95
Median age at first event (years)
Whole population 38.45 37.16 40.06
Only index persons 37.11 35.78 38.93

-FinnGen-

Key figures

All Female Male
Number of individuals 8209 5244 2965
Unadjusted period prevalence (%) 1.85 2.06 1.49
Median age at first event (years) 38.17 35.97 42.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_BIPO and mortality.

Females

Parameter HR [95% CI] p-value
F5_BIPO 2.479 [2.24, 2.74] < 0.001
Birth year 0.998 [0.99, 1.01] 0.539

During the follow-up period (1.1.1998 — 31.12.2019), 2510 out of 27905 females with F5_BIPO died.

Males

Parameter HR [95% CI] p-value
F5_BIPO 2.739 [2.49, 3.01] < 0.001
Birth year 0.987 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 3269 out of 20913 males with F5_BIPO died.

Mortality risk

Mortality risk for people of age

years, who have F5_BIPO.

N-year risk Females Males
1 0.24% 0.526%
5 1.509% 3.107%
10 3.821% 7.215%
15 7.48% 14.366%
20 12.918% 23.536%

Relationships between endpoints

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Index endpoint: F5_BIPO – Bipolar affective disorders

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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