anorexia nervosa: A disorder most often seen in adolescent females characterized by a refusal to maintain a minimally normal body weight, an intense fear of gaining weight, a disturbance in body image, and, in postmenarcheal females, the development of amenorrhea.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2445 |
4. Check minimum number of eventsNone |
2445 |
5. Include endpointsNone |
2445 |
6. Filter based on genotype QC (FinnGen only) |
2352 |
Control definitions (FinnGen only)
Control exclude
F5_BEHAVE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Anorexia (incl.atypical)
based on the number of shared cases.
Similar with more cases:
- Eating disorders
- Behavioural syndromes associated with physiological disturbances and physical factors
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 30794 | 23074 | 7457 |
| Only index persons | 25075 | 20032 | 5043 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.55 | 0.66 | 0.21 |
| Only index persons | 0.63 | 0.74 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 20.13 | 17.91 | 25.85 |
| Only index persons | 17.62 | 17.10 | 19.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2352 | 1875 | 477 |
| Unadjusted period prevalence (%) | 0.64 | 0.74 | 0.24 |
| Median age at first event (years) | 19.15 | 18.21 | 22.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_ANOREX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ANOREX | 3.121 [2.52, 3.86] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.315 |
During the follow-up period (1.1.1998 — 31.12.2019), 338 out of 13011 females with F5_ANOREX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ANOREX | 3.078 [2.19, 4.32] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 157 out of 1192 males with F5_ANOREX died.
Mortality risk
Mortality risk for people of age
years, who have F5_ANOREX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.26% | 0.477% |
| 5 | 1.72% | 3.486% |
| 10 | 4.648% | 8.526% |
| 15 | 9.088% | 15.874% |
| 20 | 15.515% | 25.246% |
Relationships between endpoints
↥Index endpoint: F5_ANOREX – Anorexia (incl.atypical)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data