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Testicular hypofunction

DOID EFO Endpoint Browser PheWeb

E4_TESTICHYPO

testicular disease: A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only males

207946

2. Check conditions

None

207946

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E29.1#
  • Hospital discharge: ICD-9 — 257[1-2]
  • Hospital discharge: ICD-8 — 2571
  • Cause of death: ICD-10 — E29.1#
  • Cause of death: ICD-9 — 257[1-2]
  • Cause of death: ICD-8 — 2571
  • KELA reimbursements: KELA codes — ANY
  • KELA reimbursements: ICD-10 — E29.1#

3 out of 7 registries used, show all original rules.

1039

4. Check minimum number of events

None

1039

5. Include endpoints

None

1039

6. Filter based on genotype QC (FinnGen only)

972

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E29
Name in latin Hypofunctio testium

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4793 - 4793
Only index persons 4698 - 4698
Unadjusted period prevalence (%)
Whole population 0.13 - 0.13
Only index persons 0.18 - 0.18
Median age at first event (years)
Whole population - - 48.75
Only index persons - - 48.71

-FinnGen-

Key figures

All Female Male
Number of individuals 972 - 972
Unadjusted period prevalence (%) 0.49 - 0.49
Median age at first event (years) 51.95 - 51.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint E4_TESTICHYPO and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
E4_TESTICHYPO 1.58 [1.3, 1.91] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 243 out of 2410 males with E4_TESTICHYPO died.

Mortality risk

Mortality risk for people of age

years, who have E4_TESTICHYPO.

N-year risk Females Males
1 No data 0.265%
5 No data 1.557%
10 No data 4.102%
15 No data 7.786%
20 No data 13.192%

Relationships between endpoints

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Index endpoint: E4_TESTICHYPO – Testicular hypofunction

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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