Testicular dysfunction, other/unspecified

E4_TESTICDYSNAS

testicular disease: A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only males

207946

2. Check conditions

None

207946

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E29.8, E29.9
  • Hospital discharge: ICD-9 257[8-9]
  • Hospital discharge: ICD-8 2579
  • Cause of death: ICD-10 E29.8, E29.9
  • Cause of death: ICD-9 257[8-9]
  • Cause of death: ICD-8 2579

2 out of 7 registries used, show all original rules.

131

4. Check minimum number of events

None

131

5. Include endpoints

None

131

6. Filter based on genotype QC (FinnGen only)

126

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1111 - 1111
Only index persons 1058 - 1058
Unadjusted period prevalence (%)
Whole population 0.03 - 0.03
Only index persons 0.04 - 0.04
Median age at first event (years)
Whole population - - 39.11
Only index persons - - 39.11

-FinnGen-

Key figures

All Female Male
Number of individuals 126 - 126
Unadjusted period prevalence (%) 0.06 - 0.06
Median age at first event (years) 50.87 - 50.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint E4_TESTICDYSNAS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
E4_TESTICDYSNAS 1.564 [1.05, 2.32] 0.026
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 694 males with E4_TESTICDYSNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_TESTICDYSNAS.

N-year risk Females Males
1 No data 0.294%
5 No data 1.847%
10 No data 4.324%
15 No data 8.11%
20 No data 13.644%

Relationships between endpoints

Index endpoint: E4_TESTICDYSNAS – Testicular dysfunction, other/unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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