No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
459824 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
50872 |
6. Filter based on genotype QC (FinnGen only) |
49055 |
Control definitions (FinnGen only)
Control exclude
AUTOIMMUNE
Control conditions
not E4_HYTHY_AI_EXCL
Extra metadata
First used in FinnGen datafreeze
DF7
Similar endpoints
↥List of similar endpoints to
Hypothyroidism, strict autoimmune
based on the number of shared cases.
Similar with more cases:
- Hypothyroidism, other/unspecified
- Hypothyroidism (congenital or acquired)
- Hypothyreosis and Thyroxine purchase for inclusion criteria
- Disorders of the thyroid gland
- Autoimmune diseases
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 419373 | 331912 | 84867 |
| Only index persons | 387019 | 309390 | 77629 |
| Unadjusted period prevalence (%) | |||
| Whole population | 8.02 | 9.51 | 2.37 |
| Only index persons | 9.69 | 11.37 | 2.96 |
| Median age at first event (years) | |||
| Whole population | 56.15 | 55.15 | 60.28 |
| Only index persons | 55.15 | 54.09 | 59.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 49055 | 39310 | 9745 |
| Unadjusted period prevalence (%) | 13.34 | 15.44 | 4.89 |
| Median age at first event (years) | 52.69 | 50.75 | 60.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYTHY_AI_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYTHY_AI_STRICT | 0.912 [0.85, 0.98] | 0.018 |
| Birth year | 0.999 [0.99, 1.01] | 0.764 |
During the follow-up period (1.1.1998 — 31.12.2019), 33736 out of 253550 females with E4_HYTHY_AI_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYTHY_AI_STRICT | 1.176 [1.07, 1.29] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 16974 out of 70315 males with E4_HYTHY_AI_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYTHY_AI_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.075% | 0.248% |
| 5 | 0.514% | 1.345% |
| 10 | 1.337% | 3.449% |
| 15 | 2.801% | 6.653% |
| 20 | 4.992% | 11.122% |
Relationships between endpoints
↥Index endpoint: E4_HYTHY_AI_STRICT – Hypothyroidism, strict autoimmune
GWS hits: 199
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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