No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
91 |
4. Check minimum number of eventsNone |
91 |
5. Include endpointsNone |
91 |
6. Filter based on genotype QC (FinnGen only) |
90 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E27
Name in latin
Hyperfunctio medullae glandulae suprarenalis
Similar endpoints
↥List of similar endpoints to
Adrenomedullary hyperfunction
based on the number of shared cases.
Similar with more cases:
- Other disorders of adrenal gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 589 | 326 | 256 |
| Only index persons | 521 | 296 | 225 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 57.31 | 57.45 | 57.21 |
| Only index persons | 56.12 | 56.57 | 55.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 90 | 48 | 42 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 52.99 | 50.44 | 55.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_ADREMEDHYPER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ADREMEDHYPER | 2.134 [1.49, 3.05] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.122 |
During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 254 females with E4_ADREMEDHYPER died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_ADREMEDHYPER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.217% | No data |
| 5 | 1.264% | No data |
| 10 | 2.879% | No data |
| 15 | 5.587% | No data |
| 20 | 9.629% | No data |
Relationships between endpoints
↥Index endpoint: E4_ADREMEDHYPER – Adrenomedullary hyperfunction
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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