≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Other adrenocortical overactivity

DOID Endpoint Browser PheWeb

E4_ADREACT

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E27.0
  • Hospital discharge: ICD-9 — 2553A
  • Hospital discharge: ICD-8 — 25508
  • Cause of death: ICD-10 — E27.0
  • Cause of death: ICD-9 — 2553A
  • Cause of death: ICD-8 — 25508

2 out of 7 registries used, show all original rules.

191

4. Check minimum number of events

None

191

5. Include endpoints

None

191

6. Filter based on genotype QC (FinnGen only)

181

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E27
Name in latin Alia hyperfunctio adrenocorticalis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4574 3566 1002
Only index persons 3335 2615 720
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.03
Only index persons 0.08 0.10 0.03
Median age at first event (years)
Whole population 7.91 7.69 8.52
Only index persons 8.08 7.85 8.90

-FinnGen-

Key figures

All Female Male
Number of individuals 181 148 33
Unadjusted period prevalence (%) 0.05 0.06 0.02
Median age at first event (years) 15.46 8.60 46.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

↥

Association

Association between endpoint E4_ADREACT and mortality.

Females

Parameter HR [95% CI] p-value
E4_ADREACT 4.569 [3.1, 6.73] < 0.001
Birth year 0.992 [0.98, 1.0] 0.084

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 2952 females with E4_ADREACT died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_ADREACT.

N-year risk Females Males
1 0.47% No data
5 2.272% No data
10 5.762% No data
15 11.548% No data
20 18.618% No data

Relationships between endpoints

↥

Index endpoint: E4_ADREACT – Other adrenocortical overactivity

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data