No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
191 |
4. Check minimum number of eventsNone |
191 |
5. Include endpointsNone |
191 |
6. Filter based on genotype QC (FinnGen only) |
183 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced tremor
based on the number of shared cases.
Similar with more cases:
- Other extrapyramidal and movement disorders in other diseases
- Extrapyramidal and movement disorders
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1381 | 777 | 594 |
| Only index persons | 1216 | 696 | 520 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 65.08 | 66.43 | 63.19 |
| Only index persons | 63.63 | 65.18 | 61.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 183 | 99 | 84 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 60.30 | 59.18 | 61.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_TREMOR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_TREMOR | 1.727 [1.43, 2.08] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.175 |
During the follow-up period (1.1.1998 — 31.12.2019), 219 out of 683 females with DRUGADVERS_TREMOR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_TREMOR | 2.187 [1.73, 2.77] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 212 out of 529 males with DRUGADVERS_TREMOR died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_TREMOR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.176% | 0.271% |
| 5 | 1.097% | 2.284% |
| 10 | 2.546% | 5.616% |
| 15 | 4.83% | 10.66% |
| 20 | 8.486% | 17.829% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_TREMOR – Drug-induced tremor
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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