No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
100 |
4. Check minimum number of eventsNone |
100 |
5. Include endpointsNone |
100 |
6. Filter based on genotype QC (FinnGen only) |
99 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced dystonia
based on the number of shared cases.
Similar with more cases:
- Dystonia
- Extrapyramidal and movement disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 816 | 453 | 361 |
| Only index persons | 739 | 416 | 323 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 48.80 | 52.93 | 43.66 |
| Only index persons | 46.80 | 49.61 | 43.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 99 | 62 | 37 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 45.79 | 47.97 | 42.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_DYSTON and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_DYSTON | 2.337 [1.66, 3.29] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.327 |
During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 404 females with DRUGADVERS_DYSTON died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_DYSTON | 3.612 [2.33, 5.59] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 311 males with DRUGADVERS_DYSTON died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_DYSTON.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.25% | 0.727% |
| 5 | 1.384% | 4.207% |
| 10 | 3.357% | 10.293% |
| 15 | 6.468% | 18.763% |
| 20 | 11.315% | 30.864% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_DYSTON – Drug-induced dystonia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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