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Diabetic nephropathy

DM_NEPHROPATHY

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N08.3*
  • Cause of death: ICD-10 N08.3*

2 out of 7 registries used, show all original rules.

2753

4. Check minimum number of events

None

2753

5. Include endpoints

5230

6. Filter based on genotype QC (FinnGen only)

5042

Control definitions (FinnGen only)

Control exclude DM_SEVERAL_COMPLICATIONS

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 5042 1801 3241
Unadjusted period prevalence (%) 1.30 0.71 1.63
Median age at first event (years) 60.43 55.16 63.36

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: DM_NEPHROPATHY – Diabetic nephropathy

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).