No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
441 |
4. Check minimum number of eventsNone |
441 |
5. Include endpointsNone |
441 |
6. Filter based on genotype QC (FinnGen only) |
424 |
Control definitions (FinnGen only)
Control exclude
D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D68
Name in latin
Morbus von Willebrand
Similar endpoints
↥List of similar endpoints to
Von Willebrand disease
based on the number of shared cases.
Similar with more cases:
- Other coagulation defects
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3361 | 2297 | 1052 |
| Only index persons | 3158 | 2208 | 950 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.07 | 0.03 |
| Only index persons | 0.07 | 0.08 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 28.87 | 33.42 | 18.84 |
| Only index persons | 28.84 | 33.23 | 18.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 424 | 360 | 64 |
| Unadjusted period prevalence (%) | 0.12 | 0.14 | 0.03 |
| Median age at first event (years) | 38.69 | 37.93 | 42.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_VONVILLEBRAND and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_VONVILLEBRAND | 1.504 [1.17, 1.94] | 0.002 |
| Birth year | 0.996 [0.99, 1.0] | 0.303 |
During the follow-up period (1.1.1998 — 31.12.2019), 103 out of 1902 females with D3_VONVILLEBRAND died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_VONVILLEBRAND | 1.609 [1.22, 2.12] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 821 males with D3_VONVILLEBRAND died.
Mortality risk
Mortality risk for people of age
years, who have D3_VONVILLEBRAND.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | 0.35% |
| 5 | 0.906% | 2.071% |
| 10 | 2.221% | 5.037% |
| 15 | 4.34% | 9.326% |
| 20 | 7.565% | 15.692% |
Relationships between endpoints
↥Index endpoint: D3_VONVILLEBRAND – Von Willebrand disease
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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