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Secondary sideroblastic anaemia

DOID Endpoint Browser PheWeb

D3_SIDEROANASCND

anemia (phenotype): ['A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin.']

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D64.1, D64.2#
  • Hospital discharge: ICD-9 — 2850B
  • Cause of death: ICD-10 — D64.1, D64.2#
  • Cause of death: ICD-9 — 2850B

2 out of 7 registries used, show all original rules.

96

4. Check minimum number of events

None

96

5. Include endpoints

None

96

6. Filter based on genotype QC (FinnGen only)

94

Control definitions (FinnGen only)

Control exclude D3_APLASTICANDOTHANAEMIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1282 722 533
Only index persons 764 448 316
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.01 0.02 0.01
Median age at first event (years)
Whole population 73.93 74.43 73.16
Only index persons 71.08 70.32 72.17

-FinnGen-

Key figures

All Female Male
Number of individuals 94 48 46
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 66.37 59.86 73.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint D3_SIDEROANASCND and mortality.

Females

Parameter HR [95% CI] p-value
D3_SIDEROANASCND 3.542 [2.71, 4.64] < 0.001
Birth year 0.994 [0.99, 1.0] 0.186

During the follow-up period (1.1.1998 — 31.12.2019), 412 out of 577 females with D3_SIDEROANASCND died.

Males

Parameter HR [95% CI] p-value
D3_SIDEROANASCND 3.319 [2.26, 4.86] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 305 out of 410 males with D3_SIDEROANASCND died.

Mortality risk

Mortality risk for people of age

years, who have D3_SIDEROANASCND.

N-year risk Females Males
1 0.2% 0.499%
5 2.037% 3.407%
10 5.222% 7.914%
15 9.388% 15.3%
20 16.198% 24.868%

Relationships between endpoints

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Index endpoint: D3_SIDEROANASCND – Secondary sideroblastic anaemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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