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Other nutritional anaemias

DOID EFO Endpoint Browser PheWeb

D3_NUTRIANAEMIAOTHER

anemia (phenotype): ['A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin.']

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D53
  • Hospital discharge: ICD-9 — 281[8-9]
  • Hospital discharge: ICD-8 — 281[3-9]
  • Cause of death: ICD-10 — D53
  • Cause of death: ICD-9 — 281[8-9]
  • Cause of death: ICD-8 — 281[3-9]

2 out of 7 registries used, show all original rules.

345

4. Check minimum number of events

None

345

5. Include endpoints

None

345

6. Filter based on genotype QC (FinnGen only)

330

Control definitions (FinnGen only)

Control exclude D3_NUTRIANAEMIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D50-D53
Name in latin Aliae anaemiae nutritionales

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6137 3333 2692
Only index persons 3304 1855 1449
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.08
Only index persons 0.06 0.07 0.06
Median age at first event (years)
Whole population 68.88 69.46 68.16
Only index persons 62.81 61.05 65.05

-FinnGen-

Key figures

All Female Male
Number of individuals 330 155 175
Unadjusted period prevalence (%) 0.08 0.06 0.09
Median age at first event (years) 63.49 58.18 68.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint D3_NUTRIANAEMIAOTHER and mortality.

Females

Parameter HR [95% CI] p-value
D3_NUTRIANAEMIAOTHER 2.436 [2.09, 2.84] < 0.001
Birth year 0.992 [0.98, 1.0] 0.076

During the follow-up period (1.1.1998 — 31.12.2019), 1095 out of 1787 females with D3_NUTRIANAEMIAOTHER died.

Males

Parameter HR [95% CI] p-value
D3_NUTRIANAEMIAOTHER 2.566 [2.12, 3.1] < 0.001
Birth year 0.987 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 1049 out of 1608 males with D3_NUTRIANAEMIAOTHER died.

Mortality risk

Mortality risk for people of age

years, who have D3_NUTRIANAEMIAOTHER.

N-year risk Females Males
1 0.188% 0.502%
5 1.359% 3.048%
10 3.342% 7.784%
15 6.272% 14.518%
20 10.55% 24.067%

Relationships between endpoints

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Index endpoint: D3_NUTRIANAEMIAOTHER – Other nutritional anaemias

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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