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Haemorrhagic disorder due to circulating anticoagulants

EFO MESH Endpoint Browser PheWeb

D3_HAEMORRHAGCIRGUANTICO

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D68.3#
  • Hospital discharge: ICD-9 — 2865
  • Hospital discharge: ICD-8 — 28650
  • Cause of death: ICD-10 — D68.3#
  • Cause of death: ICD-9 — 2865
  • Cause of death: ICD-8 — 28650

2 out of 7 registries used, show all original rules.

354

4. Check minimum number of events

None

354

5. Include endpoints

None

354

6. Filter based on genotype QC (FinnGen only)

337

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D68
Name in latin Perturbatio haemorrhagica ex anticoagulantibus circulantibus

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4217 1891 2271
Only index persons 3038 1409 1629
Unadjusted period prevalence (%)
Whole population 0.06 0.05 0.06
Only index persons 0.06 0.05 0.06
Median age at first event (years)
Whole population 78.36 81.68 75.74
Only index persons 79.55 82.39 77.09

-FinnGen-

Key figures

All Female Male
Number of individuals 337 113 224
Unadjusted period prevalence (%) 0.09 0.04 0.11
Median age at first event (years) 74.93 73.47 75.67

-FinRegistry-

Age distribution of first events

01020304050607080900.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4kAgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080900102030405060708090100110AgeIndividuals

-FinRegistry-

Year distribution of first events

19701980199019952000200520102015202020220.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6kYearIndividuals

-FinnGen-

Year distribution of first events

1970200020052010201520202023020406080100120140YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

Mortality – FinRegistry

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Association

Association between endpoint D3_HAEMORRHAGCIRGUANTICO and mortality.

Females

Parameter HR [95% CI] p-value
D3_HAEMORRHAGCIRGUANTICO 2.704 [1.88, 3.89] < 0.001
Birth year 0.989 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 431 females with D3_HAEMORRHAGCIRGUANTICO died.

Males

Parameter HR [95% CI] p-value
D3_HAEMORRHAGCIRGUANTICO 2.812 [1.94, 4.07] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 470 males with D3_HAEMORRHAGCIRGUANTICO died.

Mortality risk

Mortality risk for people of age

years, who have D3_HAEMORRHAGCIRGUANTICO.

N-year risk Females Males
1 0.18% 0.516%
5 1.195% 2.941%
10 3.153% 7.068%
15 5.678% 12.913%
20 10.172% 21.439%

Relationships between endpoints

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Index endpoint: D3_HAEMORRHAGCIRGUANTICO – Haemorrhagic disorder due to circulating anticoagulants

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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