blood coagulation disease: A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
165 |
4. Check minimum number of eventsNone |
165 |
5. Include endpoints |
822 |
6. Filter based on genotype QC (FinnGen only) |
789 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Chronic Coagulation defects
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6363 | 4116 | 2218 |
| Only index persons | 5866 | 3942 | 1924 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.12 | 0.06 |
| Only index persons | 0.12 | 0.14 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 29.42 | 33.02 | 22.61 |
| Only index persons | 29.70 | 32.84 | 23.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 789 | 605 | 184 |
| Unadjusted period prevalence (%) | 0.20 | 0.24 | 0.09 |
| Median age at first event (years) | 37.75 | 35.82 | 44.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_COAGDEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COAGDEF | 1.541 [1.28, 1.85] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.136 |
During the follow-up period (1.1.1998 — 31.12.2019), 184 out of 3408 females with D3_COAGDEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COAGDEF | 1.698 [1.39, 2.07] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 193 out of 1530 males with D3_COAGDEF died.
Mortality risk
Mortality risk for people of age
years, who have D3_COAGDEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.133% | 0.349% |
| 5 | 0.891% | 1.949% |
| 10 | 2.227% | 4.778% |
| 15 | 4.197% | 8.71% |
| 20 | 7.44% | 14.826% |
Relationships between endpoints
↥Index endpoint: D3_COAGDEF – Chronic Coagulation defects
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data