≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Folate deficiency anaemia

DOID Endpoint Browser PheWeb

D3_ANAEMIA_FOLATEDEF

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D52
  • Hospital discharge: ICD-9 — 2812
  • Hospital discharge: ICD-8 — 2812
  • Cause of death: ICD-10 — D52
  • Cause of death: ICD-9 — 2812
  • Cause of death: ICD-8 — 2812

2 out of 7 registries used, show all original rules.

250

4. Check minimum number of events

None

250

5. Include endpoints

None

250

6. Filter based on genotype QC (FinnGen only)

239

Control definitions (FinnGen only)

Control exclude D3_NUTRIANAEMIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D50-D53
Name in latin Anaemia ex deficientia folatorum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2872 1482 1356
Only index persons 2205 1156 1049
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 72.84 75.31 70.14
Only index persons 72.08 74.17 69.79

-FinnGen-

Key figures

All Female Male
Number of individuals 239 96 143
Unadjusted period prevalence (%) 0.06 0.04 0.07
Median age at first event (years) 65.52 59.18 69.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

↥

Association

Association between endpoint D3_ANAEMIA_FOLATEDEF and mortality.

Females

Parameter HR [95% CI] p-value
D3_ANAEMIA_FOLATEDEF 2.382 [1.91, 2.97] < 0.001
Birth year 0.995 [0.99, 1.0] 0.288

During the follow-up period (1.1.1998 — 31.12.2019), 554 out of 967 females with D3_ANAEMIA_FOLATEDEF died.

Males

Parameter HR [95% CI] p-value
D3_ANAEMIA_FOLATEDEF 2.386 [1.81, 3.15] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 830 males with D3_ANAEMIA_FOLATEDEF died.

Mortality risk

Mortality risk for people of age

years, who have D3_ANAEMIA_FOLATEDEF.

N-year risk Females Males
1 0.183% 0.443%
5 1.258% 2.584%
10 3.126% 6.782%
15 6.507% 13.05%
20 11.211% 21.332%

Relationships between endpoints

↥

Index endpoint: D3_ANAEMIA_FOLATEDEF – Folate deficiency anaemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data