anemia (phenotype): ['A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin.']
Anaemia in chronic diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
D3_ANAEMIAINCHRONICDISEASE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
749 |
4. Check minimum number of eventsNone |
749 |
5. Include endpointsNone |
749 |
6. Filter based on genotype QC (FinnGen only) |
707 |
Control definitions (FinnGen only)
Control exclude
D3_APLASTICANDOTHANAEMIA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Anaemia in chronic diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Aplastic and other anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5226 | 2347 | 2830 |
| Only index persons | 4405 | 1950 | 2455 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.08 |
| Only index persons | 0.08 | 0.07 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 73.92 | 74.67 | 73.28 |
| Only index persons | 73.78 | 74.70 | 73.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 707 | 258 | 449 |
| Unadjusted period prevalence (%) | 0.18 | 0.10 | 0.23 |
| Median age at first event (years) | 69.11 | 66.06 | 70.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_ANAEMIAINCHRONICDISEASE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ANAEMIAINCHRONICDISEASE | 5.038 [3.9, 6.51] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.886 |
During the follow-up period (1.1.1998 — 31.12.2019), 1200 out of 1901 females with D3_ANAEMIAINCHRONICDISEASE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ANAEMIAINCHRONICDISEASE | 5.365 [3.81, 7.55] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 1351 out of 2167 males with D3_ANAEMIAINCHRONICDISEASE died.
Mortality risk
Mortality risk for people of age
years, who have D3_ANAEMIAINCHRONICDISEASE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.614% | 1.111% |
| 5 | 3.131% | 6.608% |
| 10 | 7.479% | 15.419% |
| 15 | 15.405% | 27.787% |
| 20 | 25.086% | 42.426% |
Relationships between endpoints
↥Index endpoint: D3_ANAEMIAINCHRONICDISEASE – Anaemia in chronic diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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