Anemia, Hemolytic, Autoimmune: Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which various types of auto-antibodies are directed against red blood cells causing their survival to be shortened and resulting in hemolytic anemia.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1224 |
4. Check minimum number of eventsNone |
1224 |
5. Include endpointsNone |
1224 |
6. Filter based on genotype QC (FinnGen only) |
1172 |
Control definitions (FinnGen only)
Control exclude
D3_APLASTICANDOTHANAEMIA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D60-D64
Name in latin
Anaemia posthaemorrhagica acuta
Similar endpoints
↥List of similar endpoints to
Acute posthaemorrhagic anaemia
based on the number of shared cases.
Similar with more cases:
- Aplastic and other anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15654 | 8391 | 7003 |
| Only index persons | 10414 | 5848 | 4566 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.22 | 0.24 | 0.20 |
| Only index persons | 0.20 | 0.21 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 73.23 | 75.42 | 70.61 |
| Only index persons | 71.10 | 72.75 | 68.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1172 | 543 | 629 |
| Unadjusted period prevalence (%) | 0.27 | 0.21 | 0.32 |
| Median age at first event (years) | 68.67 | 65.86 | 71.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_ACUTEPOSTBLEEDANAEMIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACUTEPOSTBLEEDANAEMIA | 2.744 [2.4, 3.14] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 3269 out of 5439 females with D3_ACUTEPOSTBLEEDANAEMIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACUTEPOSTBLEEDANAEMIA | 3.312 [2.83, 3.88] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.044 |
During the follow-up period (1.1.1998 — 31.12.2019), 3031 out of 4720 males with D3_ACUTEPOSTBLEEDANAEMIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_ACUTEPOSTBLEEDANAEMIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.139% | 0.678% |
| 5 | 1.314% | 4.017% |
| 10 | 3.311% | 10.539% |
| 15 | 6.126% | 19.392% |
| 20 | 10.911% | 30.574% |
Relationships between endpoints
↥Index endpoint: D3_ACUTEPOSTBLEEDANAEMIA – Acute posthaemorrhagic anaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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