≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Acquired pure red cell aplasia [erythroblastopenia]

DOID Endpoint Browser PheWeb

D3_ACQPUREREDCLLAPLASIA

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D60
  • Hospital discharge: ICD-9 — 2848C
  • Hospital discharge: ICD-8 — 28404
  • Cause of death: ICD-10 — D60
  • Cause of death: ICD-9 — 2848C
  • Cause of death: ICD-8 — 28404

2 out of 7 registries used, show all original rules.

146

4. Check minimum number of events

None

146

5. Include endpoints

None

146

6. Filter based on genotype QC (FinnGen only)

140

Control definitions (FinnGen only)

Control exclude D3_APLASTICANDOTHANAEMIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D60-D64
Name in latin Erythroblastopenia [pura] acquisita

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1585 812 763
Only index persons 1228 642 586
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 50.27 49.87 50.40
Only index persons 51.23 50.58 51.94

-FinnGen-

Key figures

All Female Male
Number of individuals 140 72 68
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 61.50 56.19 67.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

↥

Association

Association between endpoint D3_ACQPUREREDCLLAPLASIA and mortality.

Females

Parameter HR [95% CI] p-value
D3_ACQPUREREDCLLAPLASIA 2.385 [1.8, 3.16] < 0.001
Birth year 0.998 [0.99, 1.01] 0.612

During the follow-up period (1.1.1998 — 31.12.2019), 214 out of 643 females with D3_ACQPUREREDCLLAPLASIA died.

Males

Parameter HR [95% CI] p-value
D3_ACQPUREREDCLLAPLASIA 3.507 [2.19, 5.62] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 220 out of 570 males with D3_ACQPUREREDCLLAPLASIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_ACQPUREREDCLLAPLASIA.

N-year risk Females Males
1 0.271% 0.578%
5 1.616% 3.729%
10 4.04% 9.649%
15 7.368% 16.673%
20 12.727% 26.796%

Relationships between endpoints

↥

Index endpoint: D3_ACQPUREREDCLLAPLASIA – Acquired pure red cell aplasia [erythroblastopenia]

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data