No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
479 |
4. Check minimum number of eventsNone |
479 |
5. Include endpointsNone |
479 |
6. Filter based on genotype QC (FinnGen only) |
461 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M34
Name in latin
Syndroma CREST
Similar endpoints
↥List of similar endpoints to
CR(E)ST syndrome
based on the number of shared cases.
Similar with more cases:
- Systemic sclerosis, icd10
- Systemic sclerosis
- Systemic sclerosis (FG)
- Systemic connective tissue disorders
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2272 | 1946 | 313 |
| Only index persons | 2112 | 1834 | 278 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.01 |
| Only index persons | 0.06 | 0.07 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.34 | 58.28 | 59.14 |
| Only index persons | 57.94 | 57.80 | 58.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 461 | 405 | 56 |
| Unadjusted period prevalence (%) | 0.14 | 0.16 | 0.03 |
| Median age at first event (years) | 57.24 | 57.44 | 55.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint CREST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CREST | 2.418 [2.09, 2.8] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 370 out of 1714 females with CREST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CREST | 2.657 [1.86, 3.8] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 263 males with CREST died.
Mortality risk
Mortality risk for people of age
years, who have CREST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.263% | 0.492% |
| 5 | 1.279% | 3.229% |
| 10 | 3.077% | 7.7% |
| 15 | 6.036% | 14.045% |
| 20 | 10.835% | 23.099% |
Relationships between endpoints
↥Index endpoint: CREST – CR(E)ST syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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