Later onset COPD

COPD_LATER

chronic obstructive pulmonary disease: A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • not COPD_EARLY
465126

3. Check pre-conditions, main-only, mode, registry filters

Pre-conditions: EVENT_AGE>=65

Registry filters:

  • Hospital discharge: ICD-10 J44
  • Hospital discharge: ICD-9 4912
  • Hospital discharge: ICD-8 49104
  • Cause of death: ICD-10 J44
  • Cause of death: ICD-9 4912
  • Cause of death: ICD-8 49104

2 out of 7 registries used, show all original rules.

12730

4. Check minimum number of events

None

12730

5. Include endpoints

None

12730

6. Filter based on genotype QC (FinnGen only)

12357

Control definitions (FinnGen only)

Control exclude COPD_EARLYANDLATER
Control pre-conditions DEATH_AGE>=65
Control conditions not COPD_EARLY

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 J40-J47
Name in latin Alii morbi obstructivi chronici pulmonum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 114662 34294 77648
Only index persons 71526 25168 46358
Unadjusted period prevalence (%)
Whole population 1.83 0.98 2.17
Only index persons 1.47 0.93 1.77
Median age at first event (years)
Whole population 74.21 74.61 74.05
Only index persons 74.02 74.33 73.86

-FinnGen-

Key figures

All Female Male
Number of individuals 12357 2346 10011
Unadjusted period prevalence (%) 4.25 0.92 5.03
Median age at first event (years) 73.40 72.14 73.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint COPD_LATER and mortality.

Females

Parameter HR [95% CI] p-value
COPD_LATER 2.943 [2.69, 3.22] < 0.001
Birth year 0.992 [0.98, 1.0] 0.045

During the follow-up period (1.1.1998 — 31.12.2019), 14790 out of 24678 females with COPD_LATER died.

Males

Parameter HR [95% CI] p-value
COPD_LATER 2.755 [2.5, 3.04] < 0.001
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 33995 out of 49460 males with COPD_LATER died.

Mortality risk

Mortality risk for people of age

years, who have COPD_LATER.

N-year risk Females Males
1 0.323% 0.504%
5 1.641% 2.552%
10 3.845% 6.443%
15 7.226% 12.572%
20 12.606% 20.805%

Relationships between endpoints

Index endpoint: COPD_LATER – Later onset COPD

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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