No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
592 |
4. Check minimum number of eventsNone |
592 |
5. Include endpointsNone |
592 |
6. Filter based on genotype QC (FinnGen only) |
549 |
Control definitions (FinnGen only)
Control exclude
IBD_CMV
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other/unspecified cytomegaloviral diseases
based on the number of shared cases.
Similar with more cases:
- Cytomegalovirus infection, IBD co-morbidity
- Cytomegaloviral disease
- Infections, IBD-co-morbidities
- Other viral diseases
- Certain infectious and parasitic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3534 | 1602 | 1906 |
| Only index persons | 2987 | 1369 | 1618 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 51.68 | 52.05 | 51.36 |
| Only index persons | 52.44 | 52.68 | 52.24 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 549 | 278 | 271 |
| Unadjusted period prevalence (%) | 0.12 | 0.11 | 0.14 |
| Median age at first event (years) | 53.24 | 50.52 | 56.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CMV_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CMV_NOS | 9.487 [7.39, 12.17] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.116 |
During the follow-up period (1.1.1998 — 31.12.2019), 357 out of 1188 females with CMV_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CMV_NOS | 7.015 [5.52, 8.92] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 461 out of 1368 males with CMV_NOS died.
Mortality risk
Mortality risk for people of age
years, who have CMV_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.788% | 1.214% |
| 5 | 5.163% | 7.644% |
| 10 | 11.688% | 18.808% |
| 15 | 22.762% | 32.33% |
| 20 | 36.887% | 49.928% |
Relationships between endpoints
↥Index endpoint: CMV_NOS – Other/unspecified cytomegaloviral diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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