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Multiple myeloma and malignant plasma cell neoplasms

DOID EFO Endpoint Browser

CD2_MULTIPLE_MYELOMA_PLASMA_CELL

multiple myeloma: A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C90
  • Hospital discharge: ICD-9 — 203
  • Hospital discharge: ICD-8 — 203
  • Cause of death: ICD-10 — C90
  • Cause of death: ICD-9 — 203
  • Cause of death: ICD-8 — 203

2 out of 7 registries used, show all original rules.

1545

4. Check minimum number of events

None

1545

5. Include endpoints

None

1545

6. Filter based on genotype QC (FinnGen only)

1480

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF8
Parent code in ICD-10 C81-C96
Name in latin Myeloma multiplex et neoplasmata maligna plasmacytorum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1480 653 827
Unadjusted period prevalence (%) 0.35 0.26 0.42
Median age at first event (years) 68.93 67.99 69.67

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: CD2_MULTIPLE_MYELOMA_PLASMA_CELL – Multiple myeloma and malignant plasma cell neoplasms

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).