Benign neoplasm: Transverse colon

CD2_BENIGN_TRANSVERSE_COLON

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D12.3&
  • Hospital discharge: ICD-8 21134
  • Cause of death: ICD-10 D12.3&
  • Cause of death: ICD-8 21134

2 out of 7 registries used, show all original rules.

3139

4. Check minimum number of events

None

3139

5. Include endpoints

None

3139

6. Filter based on genotype QC (FinnGen only)

3009

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D12
Name in latin Neoplasma benignum coli transversi

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 16587 7441 9089
Only index persons 15795 7174 8621
Unadjusted period prevalence (%)
Whole population 0.23 0.21 0.25
Only index persons 0.30 0.26 0.33
Median age at first event (years)
Whole population 68.07 67.76 68.33
Only index persons 67.93 67.60 68.21

-FinnGen-

Key figures

All Female Male
Number of individuals 3009 1340 1669
Unadjusted period prevalence (%) 0.70 0.53 0.84
Median age at first event (years) 67.59 66.45 68.51

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_TRANSVERSE_COLON and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_TRANSVERSE_COLON 1.299 [1.16, 1.46] < 0.001
Birth year 1.0 [0.99, 1.01] 0.947

During the follow-up period (1.1.1998 — 31.12.2019), 1139 out of 5873 females with CD2_BENIGN_TRANSVERSE_COLON died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_TRANSVERSE_COLON 1.36 [1.21, 1.53] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 2006 out of 7240 males with CD2_BENIGN_TRANSVERSE_COLON died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_TRANSVERSE_COLON.

N-year risk Females Males
1 0.122% 0.234%
5 0.829% 1.35%
10 2.124% 3.367%
15 4.219% 6.235%
20 7.572% 10.785%

Relationships between endpoints

Index endpoint: CD2_BENIGN_TRANSVERSE_COLON – Benign neoplasm: Transverse colon

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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