sigmoid neoplasm: Tumors or cancer of the sigmoid colon.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
6330 |
4. Check minimum number of eventsNone |
6330 |
5. Include endpointsNone |
6330 |
6. Filter based on genotype QC (FinnGen only) |
6100 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D12
Name in latin
Neoplasma benignum coli sigmoidei
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Sigmoid colon
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Sigmoid colon
- Benign neoplasm: Colon
- Benign neoplasm: Colon
- Benign neoplasm of colon, rectum, anus and anal canal
- Benign neoplasm of colon, rectum, anus and anal canal
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 37730 | 18380 | 19154 |
| Only index persons | 35117 | 17393 | 17724 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.53 | 0.53 | 0.54 |
| Only index persons | 0.66 | 0.64 | 0.68 |
| Median age at first event (years) | |||
| Whole population | 66.24 | 66.47 | 66.02 |
| Only index persons | 65.89 | 66.07 | 65.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6100 | 2914 | 3186 |
| Unadjusted period prevalence (%) | 1.38 | 1.14 | 1.60 |
| Median age at first event (years) | 65.75 | 64.60 | 66.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_SIGMOID_COLON and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_SIGMOID_COLON | 1.188 [1.09, 1.3] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.24 |
During the follow-up period (1.1.1998 — 31.12.2019), 3255 out of 15063 females with CD2_BENIGN_SIGMOID_COLON died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_SIGMOID_COLON | 1.343 [1.22, 1.48] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 4481 out of 15794 males with CD2_BENIGN_SIGMOID_COLON died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_SIGMOID_COLON.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.126% | 0.275% |
| 5 | 0.637% | 1.576% |
| 10 | 1.702% | 3.665% |
| 15 | 3.241% | 7.007% |
| 20 | 5.867% | 12.093% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_SIGMOID_COLON – Benign neoplasm: Sigmoid colon
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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