Benign neoplasm: Scrotum

CD2_BENIGN_SCROTUM

male reproductive organ cancer: A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only males

207946

2. Check conditions

None

207946

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D29.4&
  • Hospital discharge: ICD-9 2224
  • Hospital discharge: ICD-8 2228
  • Cause of death: ICD-10 D29.4&
  • Cause of death: ICD-9 2224
  • Cause of death: ICD-8 2228

2 out of 7 registries used, show all original rules.

137

4. Check minimum number of events

None

137

5. Include endpoints

None

137

6. Filter based on genotype QC (FinnGen only)

131

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D29
Name in latin Neoplasma benignum scroti

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1111 - 1111
Only index persons 936 - 936
Unadjusted period prevalence (%)
Whole population 0.03 - 0.03
Only index persons 0.04 - 0.04
Median age at first event (years)
Whole population - - 43.64
Only index persons - - 40.66

-FinnGen-

Key figures

All Female Male
Number of individuals 131 - 131
Unadjusted period prevalence (%) 0.07 - 0.07
Median age at first event (years) 47.54 - 47.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_SCROTUM and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_SCROTUM 1.306 [0.98, 1.74] 0.067
Birth year 0.985 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 605 males with CD2_BENIGN_SCROTUM died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_SCROTUM.

N-year risk Females Males
1 No data 0.253%
5 No data 1.561%
10 No data 3.61%
15 No data 6.871%
20 No data 11.442%

Relationships between endpoints

Index endpoint: CD2_BENIGN_SCROTUM – Benign neoplasm: Scrotum

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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