Benign neoplasm: other/unspecified salivary gland

CD2_BENIGN_SALIVARY_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D11.7, D11.9&
  • Hospital discharge: ICD-9 2102
  • Hospital discharge: ICD-8 2102
  • Cause of death: ICD-10 D11.7, D11.9&
  • Cause of death: ICD-9 2102
  • Cause of death: ICD-8 2102

2 out of 7 registries used, show all original rules.

899

4. Check minimum number of events

None

899

5. Include endpoints

None

899

6. Filter based on genotype QC (FinnGen only)

884

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7909 4345 3466
Only index persons 6218 3614 2604
Unadjusted period prevalence (%)
Whole population 0.11 0.12 0.10
Only index persons 0.12 0.13 0.10
Median age at first event (years)
Whole population 53.29 53.09 53.34
Only index persons 49.87 49.80 49.95

-FinnGen-

Key figures

All Female Male
Number of individuals 884 467 417
Unadjusted period prevalence (%) 0.20 0.18 0.21
Median age at first event (years) 51.92 48.91 55.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_SALIVARY_NOS and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_SALIVARY_NOS 1.304 [1.12, 1.52] < 0.001
Birth year 0.995 [0.99, 1.0] 0.225

During the follow-up period (1.1.1998 — 31.12.2019), 403 out of 1694 females with CD2_BENIGN_SALIVARY_NOS died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_SALIVARY_NOS 1.63 [1.38, 1.93] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 407 out of 1374 males with CD2_BENIGN_SALIVARY_NOS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_SALIVARY_NOS.

N-year risk Females Males
1 0.084% 0.371%
5 0.664% 1.865%
10 1.9% 4.564%
15 3.672% 8.531%
20 6.75% 14.404%

Relationships between endpoints

Index endpoint: CD2_BENIGN_SALIVARY_NOS – Benign neoplasm: other/unspecified salivary gland

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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