sigmoid neoplasm: Tumors or cancer of the sigmoid colon.
Benign neoplasm: Rectosigmoid junction
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_RECTOSIGMOID_JUNC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1239 |
4. Check minimum number of eventsNone |
1239 |
5. Include endpointsNone |
1239 |
6. Filter based on genotype QC (FinnGen only) |
1194 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D12
Name in latin
Neoplasma benignum junctionis rectosigmoideae
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Rectosigmoid junction
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Rectosigmoid junction
- Benign neoplasm of colon, rectum, anus and anal canal
- Benign neoplasm of colon, rectum, anus and anal canal
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7788 | 3752 | 4004 |
| Only index persons | 7330 | 3571 | 3759 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.11 | 0.11 |
| Only index persons | 0.14 | 0.13 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 67.02 | 67.20 | 66.82 |
| Only index persons | 66.65 | 66.81 | 66.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1194 | 569 | 625 |
| Unadjusted period prevalence (%) | 0.27 | 0.22 | 0.31 |
| Median age at first event (years) | 66.24 | 65.40 | 67.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_RECTOSIGMOID_JUNC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_RECTOSIGMOID_JUNC | 1.169 [1.03, 1.32] | 0.013 |
| Birth year | 0.997 [0.99, 1.01] | 0.425 |
During the follow-up period (1.1.1998 — 31.12.2019), 680 out of 3167 females with CD2_BENIGN_RECTOSIGMOID_JUNC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_RECTOSIGMOID_JUNC | 1.224 [1.08, 1.39] | 0.001 |
| Birth year | 0.986 [0.97, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 919 out of 3357 males with CD2_BENIGN_RECTOSIGMOID_JUNC died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_RECTOSIGMOID_JUNC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.101% | 0.256% |
| 5 | 0.705% | 1.504% |
| 10 | 1.808% | 3.471% |
| 15 | 3.541% | 6.366% |
| 20 | 6.085% | 10.725% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_RECTOSIGMOID_JUNC – Benign neoplasm: Rectosigmoid junction
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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