brain neoplasm: A neoplasm (disease) that involves the brain.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4300 |
4. Check minimum number of eventsNone |
4300 |
5. Include endpointsNone |
4300 |
6. Filter based on genotype QC (FinnGen only) |
4160 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D22
Name in latin
Naevus melanocyticus (cutis) trunci
Melanocytic naevi of trunk
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 29275 | 16097 | 13097 |
| Only index persons | 27901 | 15497 | 12404 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.42 | 0.46 | 0.37 |
| Only index persons | 0.53 | 0.57 | 0.47 |
| Median age at first event (years) | |||
| Whole population | 44.81 | 41.41 | 49.03 |
| Only index persons | 45.35 | 41.84 | 49.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4160 | 2488 | 1672 |
| Unadjusted period prevalence (%) | 0.92 | 0.98 | 0.84 |
| Median age at first event (years) | 51.44 | 45.45 | 60.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_MELANOCYTIC_TRUNK and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_TRUNK | 0.926 [0.8, 1.07] | 0.288 |
| Birth year | 0.996 [0.99, 1.0] | 0.388 |
During the follow-up period (1.1.1998 — 31.12.2019), 609 out of 12216 females with CD2_BENIGN_MELANOCYTIC_TRUNK died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_TRUNK | 1.086 [0.94, 1.25] | 0.248 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1132 out of 10088 males with CD2_BENIGN_MELANOCYTIC_TRUNK died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_MELANOCYTIC_TRUNK.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.11% | 0.207% |
| 5 | 0.616% | 1.207% |
| 10 | 1.534% | 3.084% |
| 15 | 2.884% | 5.662% |
| 20 | 5.105% | 9.699% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_MELANOCYTIC_TRUNK – Melanocytic naevi of trunk
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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