brain neoplasm: A neoplasm (disease) that involves the brain.
Melanocytic naevi, other sites/unspecified
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_MELANOCYTIC_NOS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2774 |
4. Check minimum number of eventsNone |
2774 |
5. Include endpointsNone |
2774 |
6. Filter based on genotype QC (FinnGen only) |
2692 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D22
Name in latin
Naevus melanocyticus non specificatus
Similar endpoints
↥List of similar endpoints to
Melanocytic naevi, other sites/unspecified
based on the number of shared cases.
Similar with more cases:
- Melanocytic naevi, other sites/unspecified
- Melanocytic naevi
- Melanocytic naevi
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17921 | 10632 | 7232 |
| Only index persons | 17173 | 10310 | 6863 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.26 | 0.30 | 0.20 |
| Only index persons | 0.33 | 0.38 | 0.26 |
| Median age at first event (years) | |||
| Whole population | 46.63 | 44.10 | 50.35 |
| Only index persons | 46.96 | 44.28 | 50.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2692 | 1663 | 1029 |
| Unadjusted period prevalence (%) | 0.60 | 0.65 | 0.52 |
| Median age at first event (years) | 53.18 | 48.72 | 60.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_MELANOCYTIC_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_NOS | 0.99 [0.86, 1.14] | 0.892 |
| Birth year | 0.999 [0.99, 1.01] | 0.747 |
During the follow-up period (1.1.1998 — 31.12.2019), 535 out of 7816 females with CD2_BENIGN_MELANOCYTIC_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_NOS | 0.989 [0.85, 1.15] | 0.881 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 635 out of 5629 males with CD2_BENIGN_MELANOCYTIC_NOS died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_MELANOCYTIC_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.105% | 0.211% |
| 5 | 0.691% | 1.035% |
| 10 | 1.699% | 2.722% |
| 15 | 3.148% | 5.373% |
| 20 | 5.272% | 9.206% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_MELANOCYTIC_NOS – Melanocytic naevi, other sites/unspecified
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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