cutaneous melanoma: A primary melanoma arising from atypical melanocytes in the skin. Precursor lesions include acquired and congenital melanocytic nevi, and dysplastic nevi. Several histologic variants have been recognized, including superficial spreading melanoma, acral lentiginous melanoma, nodular melanoma, and lentigo maligna melanoma.
Melanocytic naevi of ear and external auricular canal
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_MELANOCYTIC_EAR
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
184 |
4. Check minimum number of eventsNone |
184 |
5. Include endpointsNone |
184 |
6. Filter based on genotype QC (FinnGen only) |
180 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D22
Name in latin
Naevus melanocyticus (cutis) auriculae
Similar endpoints
↥List of similar endpoints to
Melanocytic naevi of ear and external auricular canal
based on the number of shared cases.
Similar with more cases:
- Melanocytic naevi of ear and external auricular canal
- Melanocytic naevi
- Melanocytic naevi
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1330 | 810 | 508 |
| Only index persons | 1251 | 778 | 473 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 49.38 | 45.07 | 56.22 |
| Only index persons | 48.91 | 44.97 | 55.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 180 | 116 | 64 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | 51.40 | 45.02 | 62.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_MELANOCYTIC_EAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_EAR | 1.145 [0.83, 1.59] | 0.414 |
| Birth year | 0.995 [0.99, 1.0] | 0.269 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 636 females with CD2_BENIGN_MELANOCYTIC_EAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_EAR | 1.019 [0.75, 1.38] | 0.902 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 390 males with CD2_BENIGN_MELANOCYTIC_EAR died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_MELANOCYTIC_EAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | 0.203% |
| 5 | 0.676% | 1.113% |
| 10 | 1.628% | 2.915% |
| 15 | 3.122% | 5.533% |
| 20 | 5.382% | 9.116% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_MELANOCYTIC_EAR – Melanocytic naevi of ear and external auricular canal
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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