Benign neoplasm: Conjunctiva

CD2_BENIGN_CONJUNCTIVA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D31.0&
  • Hospital discharge: ICD-9 2243
  • Hospital discharge: ICD-8 22400
  • Cause of death: ICD-10 D31.0&
  • Cause of death: ICD-9 2243
  • Cause of death: ICD-8 22400

2 out of 7 registries used, show all original rules.

1037

4. Check minimum number of events

None

1037

5. Include endpoints

None

1037

6. Filter based on genotype QC (FinnGen only)

1008

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D31
Name in latin Neoplasma benignum conjunctivae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9125 4799 4289
Only index persons 8425 4519 3906
Unadjusted period prevalence (%)
Whole population 0.13 0.14 0.12
Only index persons 0.16 0.17 0.15
Median age at first event (years)
Whole population 46.75 47.84 45.62
Only index persons 46.86 48.15 45.37

-FinnGen-

Key figures

All Female Male
Number of individuals 1008 598 410
Unadjusted period prevalence (%) 0.22 0.23 0.21
Median age at first event (years) 53.03 50.55 56.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_CONJUNCTIVA and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_CONJUNCTIVA 0.859 [0.75, 0.98] 0.028
Birth year 0.999 [0.99, 1.01] 0.882

During the follow-up period (1.1.1998 — 31.12.2019), 382 out of 3763 females with CD2_BENIGN_CONJUNCTIVA died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_CONJUNCTIVA 0.942 [0.82, 1.08] 0.393
Birth year 0.988 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 471 out of 3295 males with CD2_BENIGN_CONJUNCTIVA died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CONJUNCTIVA.

N-year risk Females Males
1 0.092% 0.141%
5 0.466% 1.121%
10 1.353% 2.747%
15 2.688% 5.275%
20 5.024% 8.955%

Relationships between endpoints

Index endpoint: CD2_BENIGN_CONJUNCTIVA – Benign neoplasm: Conjunctiva

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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