choroid cancer: Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1836 |
4. Check minimum number of eventsNone |
1836 |
5. Include endpointsNone |
1836 |
6. Filter based on genotype QC (FinnGen only) |
1764 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D31
Name in latin
Neoplasma benignum chorioideae
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Choroid
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Choroid
- Benign neoplasm of eye and adnexa
- Benign neoplasm of eye and adnexa
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11875 | 7347 | 4502 |
| Only index persons | 11506 | 7160 | 4346 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.21 | 0.13 |
| Only index persons | 0.23 | 0.26 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 65.87 | 65.27 | 66.87 |
| Only index persons | 65.71 | 65.12 | 66.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1764 | 1066 | 698 |
| Unadjusted period prevalence (%) | 0.39 | 0.42 | 0.35 |
| Median age at first event (years) | 64.95 | 62.60 | 68.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_CHOROID and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_CHOROID | 0.835 [0.74, 0.94] | 0.002 |
| Birth year | 0.994 [0.98, 1.0] | 0.195 |
During the follow-up period (1.1.1998 — 31.12.2019), 842 out of 5914 females with CD2_BENIGN_CHOROID died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_CHOROID | 0.838 [0.73, 0.97] | 0.016 |
| Birth year | 0.989 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 654 out of 3580 males with CD2_BENIGN_CHOROID died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_CHOROID.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | 0.147% |
| 5 | 0.466% | 1.013% |
| 10 | 1.192% | 2.645% |
| 15 | 2.354% | 4.999% |
| 20 | 4.394% | 8.679% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_CHOROID – Benign neoplasm: Choroid
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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