Benign neoplasm: Caecum

CD2_BENIGN_CAECUM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D12.0&
  • Hospital discharge: ICD-8 21132
  • Cause of death: ICD-10 D12.0&
  • Cause of death: ICD-8 21132

2 out of 7 registries used, show all original rules.

3220

4. Check minimum number of events

None

3220

5. Include endpoints

None

3220

6. Filter based on genotype QC (FinnGen only)

3121

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D12
Name in latin Neoplasma benignum caeci

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17590 9035 8500
Only index persons 16774 8728 8046
Unadjusted period prevalence (%)
Whole population 0.25 0.26 0.24
Only index persons 0.31 0.32 0.31
Median age at first event (years)
Whole population 69.48 69.23 69.74
Only index persons 69.27 69.08 69.49

-FinnGen-

Key figures

All Female Male
Number of individuals 3121 1595 1526
Unadjusted period prevalence (%) 0.69 0.63 0.77
Median age at first event (years) 68.42 67.34 69.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_CAECUM and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_CAECUM 1.248 [1.11, 1.4] < 0.001
Birth year 0.991 [0.98, 1.0] 0.036

During the follow-up period (1.1.1998 — 31.12.2019), 1399 out of 7195 females with CD2_BENIGN_CAECUM died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_CAECUM 1.395 [1.23, 1.58] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 1984 out of 6799 males with CD2_BENIGN_CAECUM died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CAECUM.

N-year risk Females Males
1 0.101% 0.269%
5 0.735% 1.517%
10 1.712% 3.638%
15 3.252% 7.042%
20 5.608% 11.836%

Relationships between endpoints

Index endpoint: CD2_BENIGN_CAECUM – Benign neoplasm: Caecum

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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