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Malignant neoplasm of vulva

Endpoint Browser PheWeb

C3_VULVA_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C51
  • Cause of death: ICD-9 — 184[1-4]
  • Cause of death: ICD-8 — 1841
  • Cancer registry: Topography ICD-O-3 — C51
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2716 2716 -
Only index persons 1823 1823 -
Unadjusted period prevalence (%)
Whole population 0.08 0.08 -
Only index persons 0.07 0.07 -
Median age at first event (years)
Whole population - 71.64 -
Only index persons - 71.85 -

-FinnGen-

Key figures

All Female Male
Number of individuals 266 266 -
Unadjusted period prevalence (%) 0.10 0.10 -
Median age at first event (years) 68.78 68.78 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_VULVA_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_VULVA_EXALLC 2.792 [2.33, 3.34] < 0.001
Birth year 0.992 [0.98, 1.0] 0.087

During the follow-up period (1.1.1998 — 31.12.2019), 931 out of 1760 females with C3_VULVA_EXALLC died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have C3_VULVA_EXALLC.

N-year risk Females Males
1 0.251% No data
5 1.421% No data
10 3.899% No data
15 7.225% No data
20 12.856% No data

Relationships between endpoints

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Index endpoint: C3_VULVA_EXALLC – Malignant neoplasm of vulva

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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