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Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system

Endpoint Browser PheWeb

C3_SPINAL_CORD_CRANIAL_AND_OTHER_CNS_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C72
  • Cause of death: ICD-9 — 192
  • Cause of death: ICD-8 — 192
  • Cause of death: excluded ICD-9 — 1921|1923|1928
  • Cancer registry: Topography ICD-O-3 — C72
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF9

Similar endpoints

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List of similar endpoints to Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

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No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population - - -
Only index persons - - -
Unadjusted period prevalence (%)
Whole population - - -
Only index persons - - -
Median age at first event (years)
Whole population - - -
Only index persons - - -

-FinnGen-

Key figures

All Female Male
Number of individuals 58 27 31
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 54.67 49.26 59.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_SPINAL_CORD_CRANIAL_AND_OTHER_CNS_EXALLC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have C3_SPINAL_CORD_CRANIAL_AND_OTHER_CNS_EXALLC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

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Index endpoint: C3_SPINAL_CORD_CRANIAL_AND_OTHER_CNS_EXALLC – Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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