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Small cell lung cancer

Endpoint Browser PheWeb

C3_SCLC_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

  • HLP_C3_SCLC
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C34
  • Cause of death: ICD-9 — 162
  • Cause of death: ICD-8 — 162
  • Cancer registry: Topography ICD-O-3 — C34
  • Cancer registry: Morphology ICD-O-3 — 8041
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not HLP_C3_SCLC

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12835 3017 9266
Only index persons 4218 1564 2654
Unadjusted period prevalence (%)
Whole population 0.23 0.09 0.26
Only index persons 0.09 0.06 0.10
Median age at first event (years)
Whole population 66.17 66.89 66.00
Only index persons 68.92 68.58 69.11

-FinnGen-

Key figures

All Female Male
Number of individuals 855 184 671
Unadjusted period prevalence (%) 0.28 0.07 0.34
Median age at first event (years) 71.03 69.11 71.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_SCLC_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_SCLC_EXALLC 54.538 [32.93, 90.32] < 0.001
Birth year 0.993 [0.99, 1.0] 0.12

During the follow-up period (1.1.1998 — 31.12.2019), 1524 out of 1725 females with C3_SCLC_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_SCLC_EXALLC 33.589 [20.6, 54.78] < 0.001
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 3042 out of 3283 males with C3_SCLC_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_SCLC_EXALLC.

N-year risk Females Males
1 4.834% 5.83%
5 20.991% 32.082%
10 46.747% 59.658%
15 71.914% 82.194%
20 91.673% 94.856%

Relationships between endpoints

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Index endpoint: C3_SCLC_EXALLC – Small cell lung cancer

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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