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Malignant neoplasm of bronchus and lung

Endpoint Browser PheWeb

C3_BRONCHUS_LUNG_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C34
  • Cause of death: ICD-9 — 162
  • Cause of death: ICD-8 — 152
  • Cause of death: excluded ICD-9 — 1620
  • Cause of death: excluded ICD-8 — 1620
  • Cancer registry: Topography ICD-O-3 — C34
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Similar endpoints

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List of similar endpoints to Malignant neoplasm of bronchus and lung based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 91377 22039 65717
Only index persons 34667 12718 21949
Unadjusted period prevalence (%)
Whole population 1.62 0.63 1.84
Only index persons 0.70 0.47 0.84
Median age at first event (years)
Whole population 68.52 69.74 68.23
Only index persons 71.02 70.84 71.13

-FinnGen-

Key figures

All Female Male
Number of individuals 7497 1827 5670
Unadjusted period prevalence (%) 2.33 0.72 2.85
Median age at first event (years) 71.72 69.16 72.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_BRONCHUS_LUNG_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_BRONCHUS_LUNG_EXALLC 18.903 [15.19, 23.52] < 0.001
Birth year 0.991 [0.98, 1.0] 0.033

During the follow-up period (1.1.1998 — 31.12.2019), 10500 out of 13312 females with C3_BRONCHUS_LUNG_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_BRONCHUS_LUNG_EXALLC 17.463 [13.83, 22.06] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 23354 out of 26645 males with C3_BRONCHUS_LUNG_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_BRONCHUS_LUNG_EXALLC.

N-year risk Females Males
1 1.54% 2.654%
5 8.907% 12.742%
10 19.96% 28.337%
15 34.621% 46.67%
20 51.971% 65.447%

Relationships between endpoints

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Index endpoint: C3_BRONCHUS_LUNG_EXALLC – Malignant neoplasm of bronchus and lung

GWS hits: 9

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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