No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Control conditions
not HLP_C3_NSCLC_ADENO
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Non-small cell lung cancer, adenocarcinoma
based on the number of shared cases.
Similar with more cases:
- Non-small cell lung cancer, adenocarcinoma
- Non-small cell lung cancer, adenocarcinoma
- Non-small cell lung cancer
- Non-small cell lung cancer
- Malignant neoplasm of bronchus and lung
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18054 | 6360 | 11187 |
| Only index persons | 10200 | 4347 | 5853 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.27 | 0.18 | 0.31 |
| Only index persons | 0.20 | 0.16 | 0.22 |
| Median age at first event (years) | |||
| Whole population | 67.80 | 68.46 | 67.54 |
| Only index persons | 69.62 | 69.59 | 69.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2064 | 774 | 1290 |
| Unadjusted period prevalence (%) | 0.52 | 0.30 | 0.65 |
| Median age at first event (years) | 70.42 | 69.09 | 71.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_NSCLC_ADENO_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_NSCLC_ADENO_EXALLC | 17.674 [13.95, 22.39] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 3181 out of 4427 females with C3_NSCLC_ADENO_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_NSCLC_ADENO_EXALLC | 15.478 [12.01, 19.95] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5300 out of 6484 males with C3_NSCLC_ADENO_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_NSCLC_ADENO_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.548% | 2.395% |
| 5 | 8.399% | 14.513% |
| 10 | 20.0% | 32.162% |
| 15 | 35.993% | 52.89% |
| 20 | 54.116% | 72.974% |
Relationships between endpoints
↥Index endpoint: C3_NSCLC_ADENO_EXALLC – Non-small cell lung cancer, adenocarcinoma
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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