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Non-small cell lung cancer

Endpoint Browser PheWeb

C3_LUNG_NONSMALL_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C34.[123457]
  • Cause of death: ICD-10 — C34.[123457]
  • Cancer registry: Topography ICD-O-3 — C34
  • Cancer registry: Morphology ICD-O-3 — 8046|8070|8140
  • Cancer registry: Behaviour codes — 3

3 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF9

Similar endpoints

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List of similar endpoints to Non-small cell lung cancer based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

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No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 55170 14551 38739
Only index persons 26307 9690 16617
Unadjusted period prevalence (%)
Whole population 0.94 0.42 1.08
Only index persons 0.53 0.36 0.63
Median age at first event (years)
Whole population 68.26 68.97 68.07
Only index persons 70.15 69.88 70.30

-FinnGen-

Key figures

All Female Male
Number of individuals 5820 1691 4129
Unadjusted period prevalence (%) 1.66 0.66 2.07
Median age at first event (years) 71.12 68.89 72.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_LUNG_NONSMALL_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_LUNG_NONSMALL_EXALLC 15.73 [12.97, 19.08] < 0.001
Birth year 0.99 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 7450 out of 10073 females with C3_LUNG_NONSMALL_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_LUNG_NONSMALL_EXALLC 14.614 [11.83, 18.06] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 16926 out of 19954 males with C3_LUNG_NONSMALL_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_LUNG_NONSMALL_EXALLC.

N-year risk Females Males
1 1.061% 2.881%
5 6.752% 13.338%
10 15.993% 29.912%
15 28.691% 50.197%
20 45.126% 68.351%

Relationships between endpoints

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Index endpoint: C3_LUNG_NONSMALL_EXALLC – Non-small cell lung cancer

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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