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Malignant neoplasm of rectum

Endpoint Browser PheWeb

C3_RECTUM_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C20
  • Cause of death: ICD-9 — 154
  • Cause of death: ICD-8 — 1541
  • Cause of death: excluded ICD-9 — 1540|154[2-3]
  • Cancer registry: Topography ICD-O-3 — C20
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 29631 12381 16608
Only index persons 17976 7802 10174
Unadjusted period prevalence (%)
Whole population 0.42 0.35 0.46
Only index persons 0.34 0.29 0.39
Median age at first event (years)
Whole population 68.81 69.27 68.51
Only index persons 68.61 68.75 68.50

-FinnGen-

Key figures

All Female Male
Number of individuals 3213 1202 2011
Unadjusted period prevalence (%) 0.81 0.47 1.01
Median age at first event (years) 67.66 65.94 68.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_RECTUM_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_RECTUM_EXALLC 2.872 [2.58, 3.2] < 0.001
Birth year 0.997 [0.99, 1.0] 0.451

During the follow-up period (1.1.1998 — 31.12.2019), 3611 out of 7384 females with C3_RECTUM_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_RECTUM_EXALLC 2.856 [2.54, 3.2] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 5472 out of 10268 males with C3_RECTUM_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_RECTUM_EXALLC.

N-year risk Females Males
1 0.293% 0.478%
5 1.652% 2.628%
10 4.253% 6.675%
15 8.371% 12.677%
20 14.45% 21.601%

Relationships between endpoints

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Index endpoint: C3_RECTUM_EXALLC – Malignant neoplasm of rectum

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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