No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleonly males |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Malignant neoplasm of prostate
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of prostate
- malignant neoplasm of male genital organs
- malignant neoplasm of male genital organs
- Malignant neoplasm
- Malignant neoplasm
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 127018 | - | 127018 |
| Only index persons | 94971 | - | 94971 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.55 | - | 3.55 |
| Only index persons | 3.63 | - | 3.63 |
| Median age at first event (years) | |||
| Whole population | - | - | 70.94 |
| Only index persons | - | - | 70.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 17258 | - | 17258 |
| Unadjusted period prevalence (%) | 8.67 | - | 8.67 |
| Median age at first event (years) | 69.15 | - | 69.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_PROSTATE_EXALLC and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_PROSTATE_EXALLC | 1.323 [1.22, 1.44] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 39320 out of 95787 males with C3_PROSTATE_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_PROSTATE_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.254% |
| 5 | No data | 1.633% |
| 10 | No data | 3.746% |
| 15 | No data | 6.869% |
| 20 | No data | 11.431% |
Relationships between endpoints
↥Index endpoint: C3_PROSTATE_EXALLC – Malignant neoplasm of prostate
GWS hits: 88
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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