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Malignant neoplasm of penis

Endpoint Browser PheWeb

C3_PENIS_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only males

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C60
  • Cause of death: ICD-9 — 187[1-4]
  • Cause of death: ICD-8 — 1870
  • Cancer registry: Topography ICD-O-3 — C60
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 933 - 933
Only index persons 644 - 644
Unadjusted period prevalence (%)
Whole population 0.03 - 0.03
Only index persons 0.02 - 0.02
Median age at first event (years)
Whole population - - 64.09
Only index persons - - 64.60

-FinnGen-

Key figures

All Female Male
Number of individuals 105 - 105
Unadjusted period prevalence (%) 0.05 - 0.05
Median age at first event (years) 65.69 - 65.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_PENIS_EXALLC and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
C3_PENIS_EXALLC 2.632 [1.92, 3.6] < 0.001
Birth year 0.988 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 282 out of 602 males with C3_PENIS_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_PENIS_EXALLC.

N-year risk Females Males
1 No data 0.614%
5 No data 3.06%
10 No data 7.709%
15 No data 14.819%
20 No data 24.305%

Relationships between endpoints

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Index endpoint: C3_PENIS_EXALLC – Malignant neoplasm of penis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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