No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleonly females |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Malignant neoplasm of ovary
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of ovary
- malignant neoplasm of female genital organs
- malignant neoplasm of female genital organs
- Malignant neoplasm
- Malignant neoplasm
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17265 | 17265 | - |
| Only index persons | 9668 | 9668 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.49 | 0.49 | - |
| Only index persons | 0.36 | 0.36 | - |
| Median age at first event (years) | |||
| Whole population | - | 62.52 | - |
| Only index persons | - | 62.49 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1436 | 1436 | - |
| Unadjusted period prevalence (%) | 0.56 | 0.56 | - |
| Median age at first event (years) | 61.36 | 61.36 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_OVARY_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_OVARY_EXALLC | 7.83 [6.88, 8.9] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.046 |
During the follow-up period (1.1.1998 — 31.12.2019), 5419 out of 8903 females with C3_OVARY_EXALLC died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have C3_OVARY_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.557% | No data |
| 5 | 3.521% | No data |
| 10 | 9.698% | No data |
| 15 | 17.455% | No data |
| 20 | 29.505% | No data |
Relationships between endpoints
↥Index endpoint: C3_OVARY_EXALLC – Malignant neoplasm of ovary
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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